2022-10-30 00:24

本文摘要:A genetic mutation that allows people to feel fully rested with fewer than six hours sleep a night has been identified by studying a family who get by on less than average. It is the second such finding in recent months.生物学家根据对一个家中的研究,找到一种


A genetic mutation that allows people to feel fully rested with fewer than six hours sleep a night has been identified by studying a family who get by on less than average. It is the second such finding in recent months.生物学家根据对一个家中的研究,找到一种能够使人到每天晚上睡眠不够6钟头的状况下得到 充份入睡的基因突变。这一家中的组员每天睡眠里时长高过平均。它是近半年来第二个对于这一难题的类似寻找。Ying-Hui Fu at the University of California, San Francisco, and her colleagues have been seeking out and studying families in which some people seem to need less sleep than normal. They have been looking for the gene variants that might be responsible, and genetically engineering these variants into mice to confirm their effect.美国加州大学美国旧金山校区的傅嫈惠和她的朋友们依然在寻找和研究这些所需要睡眠中超过平均的家中。

她们依然在寻找有可能起具有的基因变异,并根据基因技术性将这种基因变异的基因嵌入耗子身体以确认其具有。Her team has found several mutations make people need less sleep. In August, Fus team reported that a mutation in a gene called ADRB1 allows 12 members of a family to sleep as little as 4.5 hours per night without feeling tired. This gene codes for a receptor protein common in a brain region called the dorsal pons, known to regulate sleep.她的精英团队早就找到几类基因突变不容易使大家务必较少的睡眠中。

2020年10月,傅嫈惠的研究工作组汇报称作,ADRB1基因突变使一个家中的12名组员每天晚上只入睡4.5钟头而会倍感疲倦。这类基因为一种受体蛋白编号,这类蛋白质在人的大脑中的脑桥骨间地区非常少见,这一地区部门管理调整睡眠中。Now the team has found a mutation in a gene called NPSR1 in another family in which some people report feeling fully rested after much less sleep than average. Of the two members of this family whose sleep habits they studied, one averaged 5.5 hours a night and the other just 4.3 hours.如今,研究工作组在另一个家中中找到NPSR1基因突变,一些家庭主要成员汇报讲到,她们在睡眠中時间比较之下超过平均的状况下,仍然倍感精力旺盛。她们研究了在其中两位家庭主要成员的睡眠中习惯性,一人均值每天晚上入睡5.5钟头,另一人仅有入睡4.3钟头。

NPSR1 codes for a protein receptor in the brain known to be involved in arousal and sleep behaviour. When the team engineered the mutation into mice, they slept less without any obvious effect on health or memory.NPSR1基因为人的大脑中一种参与唤起和睡眠中不负责任的蛋白蛋白激酶编号。当研究工作组把这类突然变化基因嵌入耗子身体时,他们的睡眠中時间提升了,但对身心健康和记忆能力没明显危害。Another variation in NPSR1 has previously been linked to people requiring 20 minutes less sleep than average, based on studies of tens of thousands of people.先前对于过万人的研究寻找,NPSR1基因的另一种基因变异与所需要睡眠中時间比均值较少二十分钟的人相关。

On average, people need 8 hours sleep a night. In most people, sleeping less than 6 hours a night results in a marked decline in cognitive abilities within days. Over long periods, sleep deprivation can contribute to many disorders, including obesity, heart disease, high blood pressure, diabetes and depression.均值来讲,大家每天晚上务必8钟头的睡眠中。对大部分人而言,每天晚上睡眠不够6钟头不容易导致逻辑思维能力在几日内显著升高。长期缺乏睡眠中不容易导致很多病症,还包含增加体重、心脏疾病、血压高、糖尿病患者和忧郁症。

As far as Fus team has been able to tell, however, people who sleep less because they have one of these gene variants are healthy and dont appear to suffer any ill effects. However, to be absolutely sure would require long-term studies involving large numbers of people, which isnt feasible.殊不知,就傅嫈惠的研究工作组熟识,这些由于具有这种基因变异而睡眠中较较少的人是身心健康的,并且也许没一切负面影响。但要要想基本上确定,就务必进行涉及很多群体的长时间研究,它是不脱离实际的。Right now, we cannot say for sure, says Fu.傅嫈惠讲到:“如今,大家还但是于认可。”In theory, if these gene variants provided a big advantage, evolution should have made them common – yet they appear to be rare. It might be, say, that sleeping less only became an advantage after the development of lights. But other advantageous gene variants that appeared only recently in human history, such as those allowing adults to digest milk, became widespread very rapidly.从理论上谈,假如这种基因变异获得了一个巨大的优点,演变理应不容易使他们看起来普遍,但现阶段显而易见还非常少见。


It might be possible to develop drugs that mimic the effects of these mutations. However, as NPSR1 is also involved in processes such as stress, anxiety and fear, there is a risk of nasty side effects.研究工作人员必须产品研发效仿这种基因突变的药品,但因为NPSR1基因也与工作压力、心态和躁动不安等心态相关,因而有可能导致相当严重的不良反应。Expect more reports soon. Fu say her team has already discovered more sleep-shortening mutations.大家期待直接以后能有更为多的报道。